Molecular Formula | C41H62N12O11
|
Molar Mass | 899 |
Density | 1.47±0.1 g/cm3(Predicted) |
Melting Point | >202°C (dec.) |
Solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated) |
Appearance | powder |
Color | White to Off-White |
pKa | 3.29±0.20(Predicted) |
Storage Condition | −20°C |
In vitro study | Angiotensin 1-7 (Ang-(1-7)) inhibits cultured vascular smooth muscle cell growth, whereas equal molar concentration of Ang II stimulates cell growth. Angiotensin 1-7 (Ang 1-7) abrogates the methylglyoxal-modified albumin (MGA)-stimulated myofibroblast phenotype by inhibiting the chronic stimulation of the TGF-β-ERK pathway in NRK-52E cells. |
In vivo study | Daily Angiotensin 1-7 (Ang-(1-7)) treatment (0.01-0.06 mg/kg) results in significant amelioration of DSS-induced colitis. Colitis-associated phosphorylation of p38, ERK1/2 and Akt is reduced by Ang 1-7 treatment. |